Approval of radioligand therapy for PSMA-positive mCRPC in the US1
Radioligands are an innovation driven by our increasing understanding of the molecular biology of cancer and the role of radiation in cancer care. This timeline explores the history and future of radioligand therapy (on the right) alongside other innovations in oncology (on the left).
Approval of radioligand therapy for PSMA-positive mCRPC in the US1
First positive preliminary results from a phase III trial on the use of radioligand therapy for mCRPC2
Approval of radioligand therapy for progressive midgut NETs in the US3
First approval of gene therapy (alters the person’s immune cells (T-cells) to fight cancer, also known as CAR-T therapy)4 5
Approval of radioligand therapy for progressive midgut NETs in the EU6
Approval of bone-directed radiotherapy in mCRPC in the EU7 and US8
First approval of immune checkpoint inhibitor (for malignant melanoma)9
Further studies into radioligand therapy for bone metastases10
First radioimmunotherapy approved for lymphoma in the EU11
First radioimmunotherapy approved for lymphoma in the US12
Approval of bone-directed radiotherapy for pain in bone metastases in EU countries13 14
First monoclonal antibody immunotherapy treatment approved9
Early trials of radioimmunotherapy for lymphoma15
Early studies and use of radioligand therapy for NETs16-19
Early trials of bone-directed radiotherapy for bone metastases20
First scans of endocrine-related tumours using targeted radioisotopes21 22
First anti-cancer vaccine against hepatitis B virus (a risk factor for liver cancer)4
First hormone therapy approved that blocks the effect of oestrogen9
First use of chemotherapy after surgery (known as adjuvant chemotherapy)4
First PET scanner developed23
First use of chemotherapy4
Early trials of radioactive strontium to treat metastatic bone cancer24
Discovery of hormone therapy for prostate cancer9
First use of radioiodine to treat thyroid cancer (this was the first example of using a radionuclide for cancer treatment)25
First approach combining surgery and radiation9
First use of radiotherapy to cure cancer4
For more information about this project, contact us at info@radioligandtherapy.com
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